Preheat oven to 425 degrees F. Line baking sheet with foil or parchment paper.
Place the cauliflower on the baking sheet, drizzle with oil, garlic powder, salt, and pepper, and toss to combine. Arrange in an even layer.
Roast until golden-brown and beginning to crisp, about 20-25 minutes.
Remove the cauliflower from oven. Pour the hot sauce over the cauliflower and use a spatula to toss until the florets are evenly coated. Return to the oven and roast until crispy, 5 to 10 minutes more.